Effect of methanolic extract of bark of Prosopis cineraria (L.) Druce on milk induced leukocytosis and eosinophilia in the management of asthma
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Abstract
Objective: To evaluate the effect of methanolic extract of bark of Prosopis cineraria (L.) Druce for the management of asthma. Methods: In the present study, methanolic extract of bark of Prosopis cineraria (L.) Druce at doses of 100 and 200 mg/kg b.wt i.p was evaluated for the assessment of its anti-asthmatic activity using milk induced leukocytosis and eosinophilia, oxidative stress analysis in liver and kidney along with histopathological changes in trachea of mice. Results: The results of the present investigation showed that methanolic extract of bark of Prosopis cineraria at (100 and 200 mg/kg b.wt, i.p) significantly decreased milk induced leukocytosis and eosinophilia, effective towards restoration of enhanced level of lipid peroxidation and reduced level of GSH and SOD in liver and kidney and showed a reduction in the thickness of the tracheal wall and cartilage along with inflammatory cells in mice in a dose dependent manner when compared with control group Conclusion: It can be concluded that methanolic extract of bark of Prosopis cineraria (L.) Druce may be used in the management of asthma.