Chemical composition and antimicrobial activity of Tanacetum tomentellum (Boiss.) Grierson essential oil from Turkey

Abstract

The chemical composition of essential oil obtained by hydrodistillation from the dried aerial parts of Tanacetum tomentellum (Boiss.) Grierson (Asteraceae) was analysed by GC-FID and GC-MS. Eighty-eight compounds, constituting about 84.1% of the total oil, were identified. The main constituents were camphor (9.4%), linalool (7.6%), α-terpineol (7.1%), trans-pinocarveol (5.3%) and trans-verbenol (4.5%). The oil was evaluated for antimicrobial and antimalarial activity. The oil showed antifungal activity against Cryptococcus neoformans with an IC50 value of 45 μg/mL, while it showed no antimicrobial activity against other tested microorganisms (Candida albicans, Aspergillus fumigatus, Staphylococcus aureus methicillin-resistant S. aureus, Pseudomonas aeruginosa and Mycobacterium intracellulare) up to a concentration of 200 μg/mL. No antimalarial activity was observed against chloroquine sensitive and chloroquine resistant strains of Plasmodium falciparum up to 15.9 μg/mL. We report for the first time the essential oil composition and biological activity of T. tomentellum