Development And Evaluation Of A New Spectrophotometric Method For Determination Of Amlodipine In Its Pure And Pharmaceutical Forms Using Zinc Oxide Nanoparticles

Abstract

The research includes developing a simple and accurate spectrophotometric method for the determination of amlodipine (AMD) in its pure and pharmaceutical preparations with zinc oxide nanoparticles (ZnO) using water as a solvent to form a complex that gave the highest absorption at the wavelength 364 nm. Beer's law limits were 10-100 μg.ml-1. The correlation coefficient was 0.9973, the molar absorptivity was 1013.72 l.mol-1.cm-1, and the Sandel sensitivity was 0.4 μg.cm -2.
The method was applied in the estimation of AMD in pharmaceutical preparations, and the results obtained from the composition of the resulting compound were consistent and accurate, as the Rec values ranged (96.6429 - 102.7166) while the RSD % values ranged (0.4973 -1.2813) , the detection limit (0.0184 μg.ml-1) , the quantitative limit (0.125 μg.ml-1 ) and the molar absorptivity was 654.2024 l.mol-1.cm-1. and the Sandel sensitivity was 0.625 μg.cm -2.The method for the determination of (AMD) has also been successfully applied in its pharmaceutical preparations.