Characterization, Antioxidant And Biological Activity Of 1,3-Thiazolidine-4-One Derivatives Synthesized From Azomethine Compounds

Abstract

The most common method was used to prepare azomethine compounds, which is the method of thermal condensation of the amino group in primary aromatic amines containing one amino group or two amine groups, with a carbonyl group or two carbonyl groups in the aromatic aldehydes, through refluxing process in absolute ethanol with the addition of drops from glacial acetic acid as a catalyst. By cycloaddition of thioglyocolic acid with various azomethine compounds in anhydrous 1,4-dioxane under reflux conditions, new compounds of 2,3-disubstituted-1,3-thiazolidine-4-one were synthesized. The end points of all reactions are checked by TLC. The products were identified using FT-IR and 1H-NMR spectroscopy and mass spectra. After confirming the processes for preparing the final compounds, their effectiveness anti-oxidant and against specific types of pathogenic bacteria and pathogenic fungi was evaluated, and the results were good at some concentrations.