Acute And Sub Acute Toxicity Of Methanolic Extract Of Sphaeranthus Amaranthoides

Abstract

Sphaeranthus amaranthoides (SA) is one of the most popular medicinal plants used  in Siddha system.  It is used to treat blood disorders, helminthiasis, eczema, vomiting, abdominal discomfort, and also used to increase the semen consistency. It also prevents the destruction and aging of the   viscera, muscles, nerves, bones, bone marrow, blood cells etc. To date there is no documented evidence corroborating its safety. This study thus aimed to evaluate the toxicity profile of the methanolic extract of Sphaeranthus amaranthoides. Acute and Subacute toxicity changes after oral administration of methanolic extract of sphaeranthus amaranthoides (SAME) were reported in Male adult Wistar albino rats. The results demonstrate that, a single dose and short term oral intake of methanolic extract of Sphaeranthus amaranthoides caused no toxicity up to a dose of 2000 mg/kg b.w.   Thus, prolonged uses of   Sphaeranthus amaranthoides orally at lower doses and mid doses were proved to be very safe.