Vitamin D Poising Androgen/Androgen Receptor Signaling Mediated Suppression Of Tmprss2 Expression In Lungs Epithelial Cell Of Elderly Male Covid-19 Patients

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Waleed Hassan Almalki , Ahmed Alshehri , Nouf Eid Nahi Alotibi

Abstract

On 2020,March 11, the WHO proclaimed the epidemic to be a global pandemic, since COVID-19 is circulating quickly across the world.In comparison, the COVID-19 gender-disaggregated findings in several European countries suggest a comparable more among the sexes, but more extreme results in the elderly men.The S protein is known to arise from the virus surface and is the most essential for host attachment and penetration. To penetrate the cells, SARS-Cov-2 attaches to the ACE-2 and the TMPRSS-2 cell serine protease to be priming by host cell.A recent studyfindsSARS-CoV-2 spike protein primer proteaseexpression. TMPRSS2 is most abundant protein in ciliated cells and type I epithelial alveolar cells and up-regulated in human and mouse with aging.Supplementation of vitamin D(1,25-D) has demonstrated beneficial benefits in viral diseases, including influenza and HIV. The amount of 1,25-D is substantially down in serious COVID-19 patients. Immune reaction in COVID-19 patients deficient in vitamin D is strong. All this factors in enhanced mortality in COVID-19infected 1,25D3 deficient patients. Based on the versatile methodology in current COVID-19 pandemic, we hypothesized themolecular exploration of the potential therapeutic effectiveness in suppression of TMPRSS-2 expression via androgen/androgen receptor signalling.

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