Effect Of Rhodiola Rosea Root On Spatial Learning Memory, Brain Antioxidant Enzymes Activity Against Morris Water Maze Model In Mice

Abstract

Alzheimer's disease (AD) is the commenest form of dementia amongst aging adult population. The Morris Water Maze (MWM) was designed to assess hippocampal-dependent learning, such as spatial memory acquisition and long-term spatial memory.
This study was aimed to evaluate Nootropic potential of Rhodiola rosea (R. rosea),methanoilcextract of R. roseaeffect was assessed on Spatial learning memory, Brain antioxidant enzymes activity against Morris water maze model in miceat a dose of 300 and 500 mg/kg. The transfer latency (TL) and estimation of brain oxidative stress markers GSH,LPO, SOD and CAT.The mice treated with R.rosea (300 and 500 mg/) extracts shows Learning and memory are linked with Escape Latency (EL) and Probe Trail (PT), Decline of 14th to 21stth day and augmentation of PT by mice on 7th to 21st day in comparison to the control.The mice administered with R.rosea 300 and 500 significantly elevated the CAT, SOD and GSH levels. However, distinctly reduced the concentration of LPO. Up on treatment with Piracetam considerably enhanced the level of CAT, SOD and GSH as well as markedly lessened the level of LPO with respect to the disease control. Form the results of this experimental work, can be concluded that R.rosea is a potential natural nootropics and therefore, its popularity is increasing its usage as supplement.