Conjugated linoleic acid from Bos Indicus cow milk attenuating liver enzymes activities and Alpha fetoprotein level in Hepatocellular Carcinoma

Abstract

Conjugated linoleic acid, (CLA), has an indispensible therapeutic agent and Incidence of several diseases, including Hepatocellular carcinoma (HCC) is increasing gradually to a new peak. The main objectives of this investigation were to detect and evaluate protective ability of CLA  from cow milk on enzymatic functions of liver and ability of CLA on HCC biomarker. The analyses include, effects of  CLA, in serum level of AST,ALT,ALP, Total bilirubin, and alpha fetoprotein (AFP) fluctuations in carbon tetrachloride (CCL4), induced HCC rats. Toxicity was stimulated by CCL4 with olive oil as vehicle in the ratio of (1:1 v/v);( olive oil 5mL/kg i.p). Sylimarin was used as a reference (standard) for intoxicated animal groups. Moreover, observation of histological studies favours the biochemical changes observed. Results showed  CLA is highly potential in depleting the level of liver enzymes and AFP biomarker, based on dose regimen. These might have been due to the action of enriched phenolic content of  CLA, to get rid of free radicals. Study concluded that CLA is a universal medicine and modulating biochemical changes in hepatotoxicity of liver cells induced HCC rat model.