Investigation Of Il-10 And Ifn-Γ In Visceral Leishmaniasis’s Patients Iniraq

Abstract

Background: Visceral leishmaniasis is a reticuloendothelial system infection that can have an impact on the immune system

Aim of the study: The currentstudy aimed toStudy the immunity and pathogenesis of visceral leishmaniasis through determining host-related factors levelsthat likely lead to parasite destruction and patient recovery and may be useful both for designing and evaluating immunoprophylaxis

Material and Methods: A case-control study was conducted among 50 cases of patientswith VL and 50 healthy control.who were admitted to maternity and children’s hospitalsin Iraqin the period from 1 October 2020 to 5 May 2021. Patients were diagnosed with visceral leishmaniasis according to history and clinical findings including persistent fever, hepatosplenomegaly, and pancytopenia might be seen in patients and by the IFAT test to confirm the disease's presence then Sandwich.Immunosorbent.The assay was employed forthe quantitativedetermination of human serum IL-10 and IFN-γ levels.Data were analyzed with (SPSS) version 23,Whitney, Mann test, and The Chi-square test.

Results: In the present study,The majority of the most common clinical signs observed in all hospitalized patients were fever 50(100%),pallor 50(100%),Hepatomegaly 45(90%) and Splenomegaly 48(96%),The cytokine levels of IL-10 and IFN-γ were higher significantly in patients than control groups(P < 0.01)

Conclusion: the current study has shown that IL-10 &IFN-γ are most likely to be involved in determining the fate of disease and can use as a diagnostic tool to estimate the severity of the injury as well as it may also use As criteria for follow-up treatment.