Toxicity Profile Of Herbo Marine Siddha Drug Sangu Parpam

Abstract

  The present study was carried out to investigate the toxicity profile of Herbo marine Siddha formulation Sangu Parpam. Three types of purification was done on three samples of  raw sangu and sangu Parpam was prepared from each purified sample and named as SP I,II,III. Acute and Sub-acute toxicity study was conducted as per the OECD guidelines 423 and 407 respectively. Acute toxicity study revealed Sangu Parpam I, II, III did not produce drug- related toxicity. The maximum tolerable dose obtained from the acute toxicity study is about 2000mg/kg b.wt. Sub acute toxicity study revealed Sangu Parpam I, II, III can be considered as safe and did not produce any toxic effects over a period of 28 days. Histopathological study shows normal architecture of oragans. Thus the Sangu Parpam I, II, III are safe in prescribed dose level as per the literature.