Serum Level Of IL-1β , IL-35 And IL-17A In Systemic Lupus Erythematosus

Abstract

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by the presence of autoantibodies directed against nuclear antigens.Profound functional alterations of lymphocytes have been demonstrated including hyperactivity of T and B cells, abnormal T cell-B cell interaction,dysregulated cytokine, and autoantibody production .This study was carried out in laboratories of the College of Science at Wasit University in cooperation with Alyarmook Teaching Hospital and outpatients in Wasit province for the period extended from July 2020 to August 2021.Using ELISA technique,in SLE patients, serum levels of IL-1β and IL-17A were increased significantly compared with control subjects.Whereas, serum levels of IL-35 significantly decreased in SLE patients compared with control subjects.