The Role Of Therapeutic Bee Venom Compared To Prednisolone In Male Albino Rats Induced With Arthritis

Abstract

The current study was conducted with the aim of knowing the effects of bee venom in reducing the physiological and immune effects in experimentally induced arthritis rats and comparing it with prednisolone.
24 male Albino rats were used, their ages ranged between 10-12 weeks and their weights 150-135 g. The study included conducting an experiment in laboratory animals where the animals were randomly divided into six groups (4 animals for each group), the first treatment group was injected with 0. 1 ml of formaldehyde at a concentration of 2% in the peritoneum of the right sole of the foot, twice on the first and third days of the experiment (returned as a positive control group with induced arthritis). As for the second treatment group, it included healthy animals injected intraperitoneally with bee venom at a rate of 1 mg/kg body weight in When the third treatment group (the healthy group) was injected orally with prednisolone at a rate of 5 mg/kg of body weight, and the fourth treatment group included experimentally induced arthritic animals injected intraperitoneally with bee venom at a rate of 1 mg/kg of body weight, while the fifth treatment group (the group of experimentally induced arthritis) orally with prednisolone at a rate of 5 mg/kg of body weight and finally the sixth treatment group (a group with experimentally induced arthritis) injected intraperitoneally with bee venom and b It was 1 mg/kg of body weight as it was orally dosed with prednisolone and at 5 mg/kg of body weight.
After the end of the study period, the animals in each group were sacrificed and blood samples were taken for the purpose of conducting biochemical tests
The results of the current study and for both experiments showed a significant increase (p≤0.05) in the average right foot thickness in the first treatment when compared with the control group and the rest of the study groups. The results also showed a significant decrease (p≤0.05) in body weight in the first treatment when compared with the first treatment The rest of the totals and during a period of 14
It is concluded from the current study that the experimental infection with rheumatoid arthritis caused clear negative effects, by affecting the biochemical parameters. The use of prednisolone, because prednisolone has many negative effects with long-term use.