Evaluating The Frequency Of Flt3-Tkd Among Patients Suffering Acute Myeloid Leukemia In Baghdad Province, Iraq

Abstract

Background: Molecular basis of acute myeloid leukemia (AML) is a mutation in genes that regulate cell proliferation and differentiation. Mutation in the FMS-like tyrosine kinase 3 (FLT3) receptor gene is one of the most common mutations in AML, which causes abnormal proliferation and survival of leukemic cells.This study aimed to diagnose and determine the frequency of FLT3- tyrosine kinase domain (TKD) mutation in patients with AML.
Methods: Patients with AML were evaluated for FLT3-TKD mutation with Sanger sequencing.
Results: 50 patients including 27 (54%) male and 23 (56%) female were included. The mean age was 28.7 ±9.01 years. Among all patients, just 3 (6%) subjects have FLT3-TKD mutation. There are no significant differences for gender and age between patients with mutation and without FLT3-TKD mutation (P-Value =0.53) and (P-Value =0.32), respectively.
Conclusion: Current survey indicated that the FLT3-TKD has a low incidence among AML patients in Baghdad. Further analysis with larger sample size, disease subtype evaluation, and treatment response is recommended.