A Drug‐In‐Adhesive Transdermal Patch Containing Smoke Of Anbar Nesara: Formulation And Evaluation Of Physicochemical Properties

Abstract

Backgroundand Aim: Smoke of Anbar Nesara (AN) is one of the types of smoke with wound healing properties. Many dosage forms can be considered for ease of use in patients, including transdermal patches. This study aims to prepare and evaluate physicochemical properties of transdermal patch contains smoke of Anbar Nesara (TP@AN).
Materials and Methods: In this study, smoke from burning AN was collected in propylene glycol and study byGas chromatography–mass spectrometry method. AN smoke was used to make the TP@AN. TP@AN had a 5% concentration of AN was made using the casting procedure. TP@ANwas characterized by some pharmaceutical tests as appearance, swelling, determination of surface pH, adhesion strength, disintegration time and ANrelease.
Results: The results were showed that 21 compounds were identified in the AN smoke. However,the results of the present study showed that the TP@AN had suitable characteristic in weight and volumetric swelling, surface pH and adhesion strength.The results of AN smoke release from TP@AN after 24 hours was close to 97%,
Conclusion: The results of the present study showed that patches containing smoke of AN have acceptable physicochemical properties. With further research, these transdermal patches can be used in the pharmaceutical industry. And also, be examined based on the dose used to treat various diseases.