Effect Of Zinc Oxide Nanoparticles On Activity Of Cell Line (B16) Causes Skin Cancer

Abstract

The investigation and discovery of effective drugs for skin cancer has become an important targetdue to the widespread and dangerous spread of skin cancer throughout the world, so it is necessary to study this disease and discover the nanomaterials affecting it to reach effective treatments in order to eliminate this disease. In this study, zinc oxide nanoparticles (ZnO-NPs) were prepared by chemical lysis and sol-gel method, X-ray diffraction and scanning electron microscope (SEM) were used, in addition to the study of cytotoxicity. Assays of the toxic effect of ZnO-NPs at different concentrations (6.25-100 (μg/ml) on melanoma cells using the (B16) mouse melanoma cell line, and the ex vivo Rat embryonic fibroblast (Ref) cell line And by studying the ability of ZnO-NPs to inhibit the proliferation of cancer cells, the results of this study showed that there is an inhibitory activity for the growth of these cancer cells with statistical significance (highly significant).This gives hope for a successful treatment to eliminate skin cancer using nanoparticles as a material Unconventional used in the treatment of cancer.