Fruits And Vegetables Role In Prevention Of Hepatotoxicity

Abstract

Toxicology of the liver is a significant global health problem. The Food and Drug Administration withdraws several medications from the market due to drug-induced hepatotoxicity (FDA). This study purpose is to find out in-vitro activity of methanol extracts of different parts namely pulp, peel & seed of imported vegetables and fruits against CCl4-induced hepatotoxicity. Suspension of Chicken liver cell was treated with CCl4 and utilised to assess super oxide dismutase (SOD), free radical scavanging, and lipid peroxidation (LPO). The impact was strong, owing to the antioxidants included in extracts of several exotic fruits and vegetables. Indeed, methanolic extracts of specific unused components (peel and seed) of fruits and vegetables revealed hepatoprotective activity in this investigation, but the significant hepatoprotective activity was seen between all bottle gourd pulp (vegetable) and inactive fruit pulp (imported fruit). As a result, it was established that CCl4-induced hepatotoxicity was detected with methanolic extracts of exotic fruits and vegetables.