The Role Of Plasma Interleukin 1 Beta Concentration, Body Temperature To The Extent Of Lesions In Ischemic Stroke Outcome Patients With And Without Hypertension

Abstract

Aims: This study aims to analyze plasma interleukin's role with one beta concentration, body temperature to the extent of lesions in ischemic stroke outcome patients with and without hypertension.
Background :Stroke is a leading cause of disability and remains the second leading cause of death in the world. The proinflammatory cytokines interleukin-1β (Il-1β) and Tumour Necrosis Factor-alpha (TNF-alpha) play critical roles in the pathogenesis of ischemic stroke. Interleukin-1 (IL-1) is a prototype of inflammatory cytokines with a broad impact on nerve function. Inflammatory mediators of the IL-1 family show specific cell production, expression, and release patterns. Ligands are mainly produced by glia (and some neurons), while astrocytes and neurons express IL-1RI6 signal transduction receptors. Under normal conditions, the expression of IL-1 is deficient in the brain. The hyperthermia initiated within the first 24 hours from stroke onset was independently related to larger infarct volume and higher neurological deficit
Methods : The study subjects were recruited consecutively from this study population. We took blood samples to analyze IL-1β at three ± two days after the onset of stroke by medical laboratory officers. We separated plasma samples by centrifugation and stored them frozen at -70 ° C until analyzed. We measured IL-1β concentration from plasma EDTA samples with sandwich-type high-sensitivity ELISA. The test's sensitivity is 0.09 ng / L. Functional outcome of the patient assessed using the Barthel Index in a cross-sectional manner with laboratory analysis.
Results : The study results showed no significant difference in body temperature (p= 0.97) and the lesions' area (p= 0.61). Whereas we found that IL-1 beta levels (p= 0.02) and ischemic stroke outcomes (p=0.01) to have significant differences.
Conclusion : There is a correlation between plasma Interleukin -1β levels (Il-1β) and ischemic stroke outcomes with and without hypertension