Binding Of Dna And Cytotoxicity Of Two Cu (Ii) Complexes With Co- Ligands

Abstract

The compounds [CuL(phen)] and [CuL(z)] are synthesized, characterized, and tested for biological activity (H2L=3-chloro-2-((3-chloro-2-hydroxybenzylidene)amino)phenol, Imz = imidazole , phen = 1,10-phenanthroline, and). Intercalative DNA binding is cytotoxic and anticancer in a biological investigation.IC50 values of [CuL(phen)] and [CuL(z)] are shown to be extremely promising for the human lung cancer A549 cell line and the breast cancer MCF7 cell line.The complexes [CuL(phen)] and [CuL(z)] appear to be more effective than numerous anticancer drugs tested in the human lung cancer A549 cell line.Most importantly, [CuL(phen)] and [CuL(z)] are substantially less hazardous to the normal cell line L132, as indicated by cell viability in the existence of these two compounds.