Microwave-Aided Preparation, Spectroscopic, Pharmaceutical Applicationsof Some Transition Metal Complexes Of Triazole Schiff Bases

Abstract

We describe here a method for the synthesis under the microwave irradiation of1-(4-(5-(p-tolyl)-1,3,4-thiadiazol-2-yl)phenyl)-N-(1H-1,2,4-triazole-3-yl)methenamine asSchiff base. Thissynthesis is fast,high yield %, and progresses, andpurer componentsthen used ligand to form complexeswithNi(II), Mn(II),Cu(II),and Co(II) ionsina molar ratio (1:2)(metal:ligand).All the complexes ofmetal (II) possessed a system octahedral. The use of mass, UV, and IR spectroscopy for stereochemical support has been approved alongside macro- and TGA analysis .The suggested structures for the coordinate'sarrangement are depended on their magnetic moment and UV-Vis spectra and are studied with TGA analysis.The complexes were studied using an integrated technique of applying Metzger and the Coats & Redfern calculation. Kinetics and decomposition were examined.The metal complex undergoes degradation in three stages. The metal oxides (MO) reside as the final products of the complex. In vitro testing was performed on all compounds produced from two-gram(-) and two (+)bacterial strains and two fungal strains.All of the synthesised compounds demonstrated moderate to substantial antimicrobial effects against one or more strains of bacteria.The antimicrobial activity for compounds examined by restraintefficacy and disc diffusion technology versus(HCT116)colon cancer cell line.