The Effect Of Propolis On Level Of Interleukin 17 And Interleukin 37 In Experimentally Infected Mice With Acinetobacter Baumannii

Abstract

The objective of the current study was to determine the impact of low and high different concentrations of propolis on enhancing the immune response orally in experimentally infected wounds with Acinetobacter baumannii. In this study, propolis was used at two different gradient concentrations (30, 40, 50) mg/kg and (100, 150, 200) mg/kg to enhance the immune response in mice with infected wounds through study its impact on levels of both Interleukin17 and Interleukin37. The results showed that concentrations of (30, 40, 50) mg/kg of propolis showed a higher effect than the concentration of (100, 150, 200) mg/kg in stimulating the production of IL-7, as its concentration was (125.68±6.26) pg/ml in the immunized infected and treated group, while it was reached (24.20±1.07) pg/ml in the group of the same treatment but immunized with the concentration of (100, 150, 200) mg/kg compared with an infected positive control group which reached (32.28±8.00) pg/cm3 and (54.69±0.38) pg/ml in the negative control group, the level of cytokine IL-37 was reduced in the group immunized with a concentration of (30, 40, 50) mg/kg of propolis with infected and treated wounds as it reached (3.06±0.06) pg/ml compared with (2.44±0.02) pg/ml in those immunized with concentration (100, 150, 200) mg/kg, while reached (11.54±3.72 and15.66±7.76) pg/ml in the infected control positive mice untreated and treated respectively. The study showed an increase in the concentration of IL-17 in the mice of the uninfected group and infected untreated group immunized bee venom which was (156.6±0.40) pg/ml and (147.90±4.31) pg/ml for both groups respectively, while it showed a reduction in the level of IL-37 which reached (2.89±0.90) and (3.05±0,12) pg/ml for both groups respectively.