Synthesis, Characterization, Molecular Docking Study And Biological Activity Of Serotonin Derivatives Containing Tetrazole Moiety

Abstract

Heterocyclic compounds in which Nitrogen atomes are present have a great importance among pharmaceutical compounds due to their higher activity in medicine. The new tetrazole heterocyclic serotonin derivatives were designed and synthesized through reaction of serotonin Schiff base compounds with sodium azide to form tetrazol compounds II(a-c). whole the end products were identified by physical properties, FT-IR spectroscopy,1H- NMR spectroscopy. The antibacterial activity for each end product was studied by using the manner of well diffusion and the examined products showed effect against two gram-positive (Staphylococcus aureus and Streptococcus pyogenes) and two gram-negative (Klebsiella and Escherichia coli) bacteria which compared to DMSO as control, and good activity compared to trimethoprim as astandard. For knowing that the resulted compounds interacted well with the receptors of bacteria the molecular docking was used.