Raisin Syrup Consumption Has Hematological Improvement In Mice

Abstract

Based on our last study that suggested many hematological impact of changing diet style and since raisin contains many useful materials which may have many benefits for hematological parameters, this work aims to study the curative effect of raisin extract on the hematological changes and histopathological changes of spleen resulting from changing the diet style in mice. In this study, 32 adult male Balb/c mice aged 8 weeks old were conducted. They were divided into four groups (n=8 for each); first group (abbreviated GB) fed on normal diet containing10% sheep brain extract and drink tap water, second group (abbreviated GR) fed on normal diet and drink raisin syrup at a concentration of 0.5mg/ml ad libitum, third group (abbreviated GB+R) fed on normal diet containing10% sheep brain extract and drink raisin syrup at a concentration of 0.5mg/ml ad libitum, and fourth group act as control group that fed on normal diet and drink tap water ad libitum. After 7 days, blood samples were collected from the eye of all mice and transferred into EDTA tubes to determine complete blood count, then mice were sacrificed by cervical dislocation and spleens were obtained to investigate their histopathological changes. Results showed that the deviations in the values of complete blood count as well as histopathological changes in spleen that occur in mice of GB group are improved in mice of GR and GB+R groups when compared with control group. These results indicate the beneficial effect of raisin on health status and need further investigation.