Hispathology And Effectiveness Of Wound Healing Cream Karo Oil Herbal Extract On Male Mice In North Sumatra, Indonesia

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EVA SARTIKA DASOPANG , JAMILAH NASUTION , AGUNG SUHARYANTO , RADIANSYAH HADI CHANDRA , IKBAR PRATAMA

Abstract

Karo oil is one of traditional medicine originating from North Sumatra. Karo oil has many properties including accelerating wounds healing on the skin. Karo oil is a traditional medicine in the form of oil so that it is impractical to be used because of its sticky so that a cream form is made which is more practical to be used. This study aims at determining the effectiveness of wound healing in cream preparations from the plant n-hexane extract used in the manufacture of karo oil and tissue repair in the incision observed from its hyspatology. This study used an experimental method, used test materials derived from plants which were the ingredients for making karo oil. The extract was obtained by maceration using n-hexane pa solvent. The stages of this research included the manufacture of plant n hexane extract as raw material for karo oil and formulating it into cream preparations in several concentrations, namely 2.5%, 5%, and 9%. The results shows that the cream preparation made from the karo oil plant had the effect of wound healing with the best concentration of 9% in wound healing.

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