Biomarkers Of Osteoarthritis In Pakistani Population

Abstract

Osteoarthritis, the disease mostly caused by the destruction of protective cushions of the bone is diagnosed mainly by X ray radiographs and MRI. Biomarkers like Vitamin D level, Serum Calcium level, Parathyroid hormone level, Erythrocyte Sedimentation Rate, Rheumatoid Factor, Uric Acid level, Bone Alkaline Phosphatase (BAP) level, Hyaluronic Acid (HA), High sensitivity C Reactive Protein (hs-CRP), BMI and platelet count are helpful for the early diagnosis and effective treatment of the disease. The study was performed (total 200 participants) by dividing them into 4 groups, 2 groups are of healthy controls (male and females) and 2 groups are of diseased participants (male and female). Level of all above mentioned biomarkers was assessed in male and female groups by commercially available kits and laboratory tests.Serum Calcium level, Parathyroid hormone level, Erythrocyte Sedimentation Rate, Uric Acid level, Bone Alkaline Phosphatase (BAP) level, Hyaluronic Acid (HA), High sensitivity C Reactive Protein (hs-CRP) are found significantly important (P˂ 0.0001) biomarker for osteoarthritis. While Vitamin D level, BMI, Rheumatoid Factor and platelet count are not found to be significantly important (P˃ 0.0001) biomarker for osteoarthritis. To avoid worsening of disease and early diagnosis of the disease these parameters must be measured in patients.