Therapeutic potential of peptidomimetics as antiviral agents: short review on recent progress

Abstract

The tug of war between viruses and humans existed for millions of years. The defensive mechanisms and rapid evolution of these viruses have made it difficult for researchers to progress in antiviral drug discovery. Therefore, this paper is intended to give an overview on reported drug targets via an insight on viral pathogenesis and the peptidomimetic-drugs reported till date against three most globally prevalent and deadly viruses: SARS-CoV-2, HIV, and HCV. The reason for selective illustration in this review is attributed to the proven record of antecedents reporting wide scope of peptidomimetics in development of antiviral drugs highlighting the ease of rapid mobilization of peptidomimetics for treatment of emerging viruses.