Experimental Infection Effect With C. Albicans In Female Rats Uterus

Abstract

The present study aimed to define the effect of experimental infection with albicans yeast on the histological structure of the uterus of pregnant female albino rats, in which 50 vaginal swaps of pregnant women were obtained using sterile cotton swaps from the women who attended the gynecological examination. Consultation was in hospital and some clinics in the city, and isolates were diagnosed using CHRO Magar media and the Vitek2 Compact system. Then, experimental infection was induced in the reproductive tract of female rats that were injected with a suspension of C. albicans yeast at a concentration of 1.5 × 810 cells/ml, once daily until the onset of symptoms. The results of microscopic examination of uterine tissues showed necrosis, partial detachment of the simple columnar epithelium and its desquamation in the uterine cavity, as well as infiltration of inflammatory cells and cell necrosis of the specific page and thickening of the nuclei of several cells, rupture of smooth muscle fibers in the circular muscle layer, irregular arrangement in the longitudinal muscle layer, Necrosis of the lining of the uterine glands, some of them expand into the lumen of the gland, dilation and congestion of a number of fibrous blood vessels and edema in some, an abundance of colloidal fibers and endometrial fibrosis .