Simultaneous Estimation Of Escitalopram Oxalate And Fesoterodine In Oral Dosage Forms By Validated Reverse Phase High Performance Liquid Chromatography

Abstract

A new, precise, rapid, accurate HPLC method was developed for the simultaneous estimation of Escitalopram oxalate and Fesoterodin in oral dosage forms. HPLC method for estimation of drug escitalopram in tablets of Cita S-10 (Cresent) was developed by using Kromosil C18 (250 mm x 4.6 mm) 5 μm column with mobile phase composition of acetonitrile : methanol : ammonium acetate buffer Ph 3.0 in the ratio 30:20:50 by isocratic elution technique, the flow rate was 1.0 mL /min and UV detection at 238 nm. The developed HPLC technique is a simple and accurate method for the estimation of API Escitalopram in tablet dosage forms. HPLC method for estimation of drug Fesoterodine in solid dosage form capsules of Roliten OD (Ranbaxy) was developed by using Kromosil C18 (250 mm x 4.6 mm) 5 μm column with mobile phase composition of acetonitrile: methanol: ammonium acetate buffer pH 3.0 in the ratio 30:30:40 by isocratic elution technique, the flow rate was 1.0 mL / min and UV detection at 281 nm. The correlation coefficient r2 values were found to be both the drugs 0.9997 for Escitalopram oxalate. RP-HPLC method for estimation of Fesoterodine in solid dosage form capsules of Roliten OD (Ranbaxy) was developed by using Kromosil C18 (250 mm x 4.6 mm) 5 μm column with mobile phase composition of acetonitrile: methanol: ammonium acetate buffer pH 3.0 in the ratio 30:30:40 by isocratic elution technique, the flow rate was 1.0 mL/min and UV detection at 281 nm. The correlation coefficient R2 value was found to be 0.9991 for Fesoterodine.