Systematic Study on Curcumin and Vasicine as A Novel Anti-Asthmatic Agent

Abstract

Curcumin and Vasicine are a traditional Indian medicine both are used in the treatment of bronchial asthma and their activity were analyzed by different research workers. In this study we investigated the combination effect of Curcumin and Vasicine usingIn-vitro isolated guinea pig tracheal chain and also by In-vivo allergen induced airway inflammatory mouse model. In In-vitro method initially responses were recorded with histamine.  After giving wash response were recorded in presence of single constituent and in combination. In In-vivo method after sensitized and challenged by Ovalbumin/ AloH, the BALB/c mice were administrated orally with the combination of Curcumin and Vasicine , total and differential count in BALF andIgE level in serum was counted using ELISA.Contraction produced by histamine was antagonized and produce relaxation by combination of Curcumin and Vasicine than single constituent. Treatment of mice with the Curcumin and Vasicine combination reduces the total and differential count of bronchoalveolar lavage fluid(BALF) and IgE serum level in the mice. The data indicate that the combination of drugs produce relaxation of smooth muscle, reduced the total and differential count and IgE, level in serum. From the result it was concluded that, Curcumin and Vasicinemay be an alternative for the conventional drug against asthma.