Possible Protective Effects Of Atorvastatin And Nigella Sativa Oil On The Kidney Of Adult Rats Exposed To Monosodium Glutamate

Abstract

Background: Monosodium glutamate (MSG) is a commonly used food additive. Many experimental animal models have recorded possible damages in some organs caused by MSG effects.
Objective: This study aimed to assess and compare the protective effects of Nigella sativa (N.S)/atorvastatin on the renal tissue on exposure to MSG.
Materials and Methods: Fourty adult male albino rats were randomly divided into four equal groups (n = 10/each): 1 (Control); 2 (MSG 35 mg/kg b.w); 3 (MSG + Atorvastatin 5 mg/kg/d); and 4 (MSG + Nigella sativa oil 400 mg/kg/d). At the end of the experiment period, rats were sacrificed and blood samples were collected for kidney functionsand serum SOD in kidney,then kidney was removed and prepared for histopathological, immunohistochemistry examination and tissue homogenate for assessments of renal malondialdehyde (MDA).
Results: MSG increased the serum level of creatinine, urea, uric acid, MDA, and renal Caspase-3 expression, while the renal expression of SOD expression was decreased in comparison to the control group. However, Co-administration of atorvastatin/nigella sativato MSG reduced serum creatinine, urea, uric acid, MDA, expression of Caspase-3and increased SOD in referral to the MSG group.
Conclusion: This study suggests that the nigella sativa and atorvastatin, are capable of ameliorating the hazardous renal effects of MSG via their antioxidant and anti-apoptotic actions.