Antiparasitic Effect Of The Silver Nanoparticles Capparis Spinosa On Immune Response In Infected Mice With Visceral Leishmaniasis

Abstract

To evaluate the efficacy of the Capparis silver nanoparticles synthesis from the leaves of the Capparis spinosa plant on the levels of immune drivers IL-12 and IFN-γ in the serum of infected laboratory mice with visceral Leishmaniasis, they were dosed with (0.1 ml/day) and pentostam drug (0.01 ml/day) for 21 days. The results showed that the level of both IFN- γ and IL-12 in mice dosed with nanoparticles was significantly decreased for three weeks compared to the positive control group.