Relationship Between The Thyroid-Stimulating Hormone (Tsh) Levels And The Presence Of Non-Alcoholic Fatty Liver Disease (Nafld) Among The Asymptomatic Egyptian Individuals

Abstract

Introduction: Thyroid hormones play a vital role in body distribution, lipid metabolism, and insulin resistance management. As a result, they could be involved in the aetiology of non-alcoholic fatty liver disease (NAFLD). However, the impact of thyroid function on NAFLD is unclear.
Aim and objectives: To evaluate the association between thyroid function and the presence of NAFLD in asymptomatic Egyptian individuals.
Subjects and methods: We selected 200 patients (both sexes) with (NAFLD) and 100 normal individuals as control. Both groups were subjected to complete clinical examination after thorough history taking, anthropometric measurements, laboratory investigations, thyroid and abdominal ultrasound.
Results: There was a statistically significant difference between the two studied groups regarding TSH, FT3 and FT4 as TSH was higher among the NAFLD group and FT3 and FT4 were lower among the NAFLD group.
Conclusion: Thyroid function, even when within normal limits, is linked to metabolic syndrome and may play a role in NAFLD. This is a noteworthy finding because it offers the possibility that lowering TSH levels could reduce metabolic syndrome risk factors and, as a result, NAFLD onset.