Formulation And Evaluation Of Doxycycline Proniosomal Gel For The Treatment Of Periodontitis

Abstract

Objective:-The main motive of this research is to enhance stability and permeation of drug by incorporation of
drug into a vesicle. It is also emphasis to improve its shelf-life.
Method: - Blank proniosomes and drug loaded with proniosomes by using coaceravation phase separation
method.
Result: - The Doxycycline proniosomal gel at bottom and elevated conc. was found out to be 4.9 % and 70.56 %
respectively. But main in- vitro study which based on comparison of Doxycycline proniosomal gel with marketed
formulation. In-vitro release study of Doxycycline proniosomal gel increased with respect to the time. The
present study claims that test drugs proniosomes of Doxycycline was shown more effective than the marketed
formulation data.
Conclusion:- According to this study the effectiveness of the Doxycycline proniosomal gel were more
effective than marketed formulation because of the vesicular drug delivery system and having natural
potential to drug absorption ability of hydrophilic drug through the membrane and it will be cost
effective than other formulation.