In-Vivo And Ex-Vivo Comparative Study Of Transdermal Patch Of Ramosetron Hydrochloride

Abstract

Ramosetron hydrochloride has the half-life 5.8 hrs. and bioavailability in the body is 50% because of first-pass effect. The dose of Ramosetron hydrochloride is 5 mcg once daily depends on weight and gender that’s why it required repeated dose. The transdermal patch of Ramosetron hydrochloride was formulated to assist the release and enhanced bioavailability of drug and patient conformance. The several formulations were fabricated by using different polymer concentration ratio. The prepared formulation was estimated during the several variables such as thickness, weight variation, drug content, moisture content, moisture uptake, folding endurance, tensile strength, in-vitro drug release and in-vitro permeation study etc. Additionally, these patches were also characterized by Fourier transforms Infrared Spectrophotometry. The comparative study has been done for ex-vivo and in-vivo studies for getting results with patches.