Alpha-Mangostin As Potent Osteogenesis And Anti-Inflammation Bioactive Material - Literature Review

Abstract

Mangosteen or Garcinia mangostana is one of the most widely grown plants in Indonesia. Many studies say that this fruit has a high antioxidant content, especially alpha-mangostin, and is widely used as a therapeutic drug. The purpose of this paper is to speak about the capacity of α-mangostin as a bioactive ingredient for anti-inflammatory and osteogenesis triggers, which is greater specific to be used for growth, bone regeneration, and wound recuperation. Literature observation is a research technique conducted via examining 18 previous studies concerning the phytochemical analysis of mangosteen peel: purposeful and fitness advantages. The outcomes of the literature evaluation defined that α-mangostin from mangosteen peel has been proven to have numerous pharmacological effects along with antioxidant anti-inflammatory. The ability of α-mangostin as a bioactive component for anti-inflammatory and triggering osteogenesis can be visible especially from bone regeneration wherein α-mangostin can cause bone recovery through the present process of a regeneration system via osteoclast absorption pastime, to hold bone high-quality. Furthermore, in terms of wound recuperation, α- mangostin in xanthones can lessen irritation or accelerate wound restoration with the absorption of mangostin and an increase in oxygen absorbance, as a result affecting the digestive gadget and renewing problematic cells or antioxidant system.