Solid Supersaturable Snedds Of Ibrutinib: Development And Evaluation

Abstract

The aim of this study was to develop a solid supersaturable self-nanoemulsifying drug delivery system (S-SNEDDS) of ibrutinib for enhancement of its solubility and dissolution rate. Crossential O94– Croduret 40SS – Carbitolare chosen based on the maximum solubility of ibrutinib and were used to construct ternary phase diagrams and 15 Formulations with Smix in 3:1 ratio and 70mg drug loading were prepared and evaluated for various tests.Out of all formulation F15 exhibited good results with highest drug release of 98.25% in 60min. LSS9 with 3% HPMC E4M as best PPI exhibited smallest droplet size of 65.4nm, a zeta potential of -17.7mV, and a PDI of 0.453. SSS1 with magnesium trisilicate as an adsorbent showed best flow characteristics and highest drug content of 99.72%. The DSC, FT-IR and stability studies confirmed the complexation of ibrutinib and amorphous state of the drug and formulation to be stable for 3months.Thus, this study indicated that the solid SNEDDS could be used as a potential drug carrier for ibrutinib with improved solubility and dissolution rate.