ACE Inhibitory Activity And Antihypertensive Effect Of Aspidopterys Cordatain DOCA-Salt-Induced Hypertension In Rats

Abstract

Hypertension is symptomatically identified with elevated blood pressure and is an instigator of other cardiovascular disorders. Both developing and developed countries are confronting this with various treatment regimens using synthetic drugs and lifestyle modifications. It needs to create plant-based antihypertensive agents to remedy the elevated blood pressure associated with other complications. In the present study, the fractions of Aspidopterys cordatawere screened for antihypertensive activity in vitro (Angiotensin-converting enzyme inhibition assay) and in vivo (DOCA salt-induced hypertension in rat) models. In the results, the methanol fraction of A. cordata exhibited significantly (p < 0.05) higher (IC50=32.82μg/ml) ACE inhibitory activity among other fractions when compared to the standard Captopril. Similarly, at the selected doses (200 mg/kg and 400 mg/kg), the methanol fraction significantly decreased (164±2.34&144.2±1.3) the mean systolic blood pressure (MSBP) in a dose-dependent manner, followed by chloroform (173.4±1.14&163.6±2.07) and ethyl acetate (175.8±1.92&164.4±1.94) fractions.