Assessment Of HOXB13 MUTATION In Prostate Cancer (Prca)

Abstract

Introduction: Carcinoma of the prostate, or Prostate cancer, has a multi genetic factors. HOXB13 is one of this factors ,specifically the G84E gremlin mutation of HOXB13, which is ported on chromosome 17.The role of HOXB13 in the development of prca was researched in this study.
Method: 60 patients diagnosed with prca in addition to 63 controls. People were classified on the report of their age and familial history, the results were classified according to the genotype, age, family history, aggressive type of prostate cancer and other types (Hum ,2013) of tumors associated with HOXB13 mutation. This study was based in PCR sequencing to determine the attendance of HOXB13 mutation in prca risk.
Result: The HOB13 mutation was found in 70% of men with a familial history of cancer, meaning they had cancer in their family before, and it was found in the majority of men over 60 years old; the variant was found in exon one of HOXB13. The HOXB13 mutation significantly raises the risk of familial prostate cancer with early onset.
Conclusion: Males with a clear family history of prostate carcinoma may benefit from screening for the G84E mutation, which could help identify those who require more frequent prostate cancer screening.