The Role of Scaling-Root Planing with a Subgingival Application of Tetracycline 0,7 % Based Chitosan Hydrogel in Periodontitis Rats’ Model (Evaluation of Clinical Parameters and Fibroblast Cell Counts on Periodontal Ligaments)

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Irma Ervina, Wilson, Winda Dwi Astuti, Martina Amalia, Armia Syahputra, Aini Hariyani Nasution, Harry Agusnar, Syafruddin Ilyas

Abstract

Introduction: Periodontal disease is a disease caused by bacterial plaque activity which cause a destruction to the
periodontium. The purpose of scaling and root planing (SRP) is to eliminate bacteria plaque, calculus and to create a smooth
root surface. Tetracycline 0,7% based chitosan hydrogel was a local delivery antibiotic (LDA)that consist of a broad-spectrum
antibiotic and an anti-collagenase property which help in regeneration of the connective tissue by increasing the secretion of
the fibroblast
Purpose: The purpose of this study is to evaluate the changes of the clinical parameters and the amount of fibroblast
cells through histological evaluation
Material and Methods: The total of 27 male Wistar rats were used in this study and divided into three group. The
interventionofthefirstgroupwas SRP with a sub gingival applicationofLDAfor 7 days. The intervention for the second group was
SRP with a sub gingival application of LDA only once. The intervention for the third group was only SRP. The clinical parameter
was evaluated at the baseline and the 14 days together with the histological evaluation.
Results: This study shows that the group with a sub gingival application of tetracycline 0,7% based chitosan hydrogel
for 7 days had the greatest change on clinical parameters and best secretion of the fibroblast cells also it was statistically
significance (p<0,05).
Conclusion:SRP with asubgingival application of tetracycline 0,7% based chitosan hydrogelfor 7 days gave the best
result on the clinical parameters changes and a better amount of fibroblast cells secretion.

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