Design, Fabrication And Evaluation Of Superporous Hydrogel BasedFloating Mini Tablets Of Nicardipine

Abstract

The present work was aimed to formulate Superporous Hydrogels based floating Minitablets of
Nicardipine hydrochloride for gastro retentive drug delivery system to improve its bioavailability. Superporous
hydrogels were prepared by using Chitosan, Ac-Di-Sol and various other polymers and evaluated for density,
porosity and mechanical strength. The dried SPH were compressed into 5mm Minitablet and filled into size ‘2’
capsule. Capsules wereevaluated for dissolution studies states that there is increase in polymeric concentration
there isa decline in drug release except for the higher concentration i.e 480 mg. NHT5 selected as the optimized
formulation based on 85% drug release. FTIR and DSC proves that there were no critical collaborations between
the drug and polymers. There are no significant changes found in the stability studies. The present study shows
that polymers like Chitosan, Ac-Di-Sol and others in combination with sodium bicarbonate as a gas generating
agent can be used to developsustained release floating tablets of Nicardipine Hydrochloride.