Success Of Syphilis Therapy In Hiv/Aids Patients Related To Cd4 Level

Abstract

Background: Syphilis and human immunodeficiency virus (HIV) infection are diseases that can be transmitted
through sexual intercourse, so it is not surprising that someone has both at the same time. Syphilis can increase
the risk of contracting the Human immunodeficiency virus (HIV) where HIV-negative people exposed to syphilis
will increase the risk of contracting up to 3-5 times. Objective: This study aims to determine the success of
syphilis therapy in HIV/AIDS patients related to CD4 levels.
Methods: This study was conducted using a quantitative analytic design, the type of research carried out was
retrospective by collecting data that had been collected previously. The population in this study were all patients
with HIV in Dr. Hospital. Soetomo Surabaya. The sample in this study was selected using a total sampling
technique involving 25 people with HIV. The data of this study were sourced from secondary data, namely
medical record data from the inpatient and outpatient of UPIPI RSUD Dr. Soetomo Surabaya in 2019. The CD4
levels obtained were analyzed by descriptive statistical tests and T-tests, while Duncan's test was used to
determine VDRL levels.
Results: The results of this study indicate that syphilis therapy has been shown to increase CD4 levels. This
increase was obtained based on the results of calculations before and before syphilis therapy. An increase in
CD4 cells in HIV patients through syphilis therapy was also accompanied by a decrease in VDRL. Based on the
test results, it is known that there are significant differences before and before therapy where VDRL decreases
every time the experiment starts from 1
st titer to 4
th titer with the average obtained (1
st titer = 11.04), (2
nd titer
= 4.72), (3
rd titer = 4.08) and (4
th titer = 1.84).
Conclusion: Syphilis therapy has been shown to be able to increase CD4 levels in syphilis patients with HIV and
reduce VDRL levels.