An Overview Of Osteoprotegerin And Its Possible Relation To Diabetic Kidney Patients

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Mohamed A. Elbana , Nagwa S. Said , Ahmed M.Baraka and Mayada M. Mousa


Background: Chronic kidney disease (CKD) is diagnosed by the persistent presence of elevated urinary albumin excretion (albuminuria), low estimated glomerular filtration rate (eGFR), or other manifestations of kidney damage. Osteoprotegerin (OPG) is largely expressed by osteoblast lineage cells of bone, epithelial cells of the gastrointestinal tract, lung, breast and skin, vascular endothelial cells, as well as B-cells and dendritic cells in the immune system , it is also known as osteoclastogenesis inhibitory factor (OCIF) or tumour necrosis factor receptor superfamily member 11B (TNFRSF11B), is a cytokine receptor of the tumour necrosis factor (TNF) receptor superfamily encoded by the TNFRSF11B gene located on chromosome 8 at position 8q24.

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