A Comparative Quantitative Study Of Selected Drugs Commercialized In Yemen With HPLC

Abstract

International free-trade growth and poor regulation of drugs have resulted in the growth of the world's trade in falsified drugs.
The best way to avoid this problem is to see technological protection. A new chromatographic method for determining Valproic
acid in pharmaceutical preparations was to be developed and validated in this study. The method parameters for validation
produced positive results and included range, linearity, accuracy, precision and retrieval. The HPLC method results were
calculated by variance analysis (ANOVA). The concluded that the HPLC method proposed is satisfactory for the quantification of
Valproic acid in pharmaceutical preparations. This research has provided quantitative evidence of the quality in both formal
markets in Yemen of the randomly selected Valproic acid. Samples were tested for quality control, by used high performance
liquid chromatography (HPLC). Three samples of Valproic acid were labeled by the same producer but therefore had different
packaging, which raised the concern that the packaging could be counterfeited. Two samples of Valproic acid were from the
same manufacturer, but the concentration of the active substance differs. However, the other two samples were reported as
non-standard because the WHO standards were not complied with. While analyzing the same Valproic acid samples, differences
in process, type and proportion of various leading brands were employed. Most of those concerned, with the effect, rather than
the technical attributes of medicines including content, appearance and source, have had limited knowledge on good quality
medicines and counterfeit medicines. A wide variety of behaviors, reporting such doubts to governments in relation to the
medical quality, finding alternative medicines, stopping the use of medicament and taking no more action on such doubts.