Curcumin And Chitosan Loaded Nano Scaffold For Targeting Chronic Wounds Through Tissue Engineering In Regenerative Medicine

Abstract

Regenerative medicine will increasingly rely on tissue engineering as a therapeutic tool. Scaffolds are an essential component of tissue engineering. The invention and enhancement of scaffolding that may be utilized to heal or regenerate a tissue or organ tissue focus on functional biomaterials research. Scaffolds made of natural polymers have lately acquired favour since they have been created more efficiently. Open deep cuts and wounds can take a long to heal and lead to infection and scars. A simple biomimetic electrospun nanofibrous antimicrobial scaffold with antioxidants was designed to address this issue. Using the electrospinning process, a chitosan-Curcumin composite nanofibrous scaffold will be created. Curcumin-chitosan NFS has been shown to have a well-regulated amount of Curcumin and Chitosan in granulation tissues, indicating it as a possible wound healing and regenerative agent. Curcumin has been proven to have anti-infective, anti-inflammatory, antioxidant, anti-mutagenic, anti-carcinogenic and anticoagulant properties. Curcumin has also been found to have wound-healing effects. It works on several phases of the natural wound healing process to speed up healing. Using Chitosan, alkaline deacetylation of chitin may reduce scarring. These scaffolds' chemical and biological properties continue to improve as new biomedical uses are discovered. Because of their many biological features, such as biodegradable, biocompatible, and bioactive, they have provided a blueprint for tissue engineering in chronic wound healing. This study concentrates on the intrinsic features of Curcumin and Chitosan and their use in chronic wound healing through tissue engineering as a viable option for regenerative medicine.