Formulation, Evaluation Of Polyherbal Dosage Form, And Study Of Its Antioxidant Activity

Abstract

Objective: The study was designed as formulation, standardization, and evaluation of polyherbal tablets prepared
for the management of antioxidants. To overcome the problem of dyspepsia in geriatric patients by the use of
polyherbal tablets and powder formulations.
Methods: Powder and tablets were prepared using aqueous root extract powder of the selected plant viz. Hibiscus
rosa sinesis, and sorghum bicolor with the help of super disintegrant addition technique using crospovidone, sodium
starch glycolate, and croscarmellose sodium in different percentages. Evaluation assessments such as the substantial
test, weight variation, hardness, friability, content uniformity, disintegration, in vitro dispersion, stability study were
carried out.
Results: Micromeritics of extracts powder were determined for all formulations, which signified good flow
properties. A substantial examination was established, which comply with official requirements for uniformity test,
and the drug content was close to 90% in all formulations. Disintegration time was observed for all formulations in
which the polyherbal formulation-3 (PHF-3) showed 1.10±0.10 min; during in vitro dispersion time, all formulations
showed appropriate dispersion in which the PHF-3 captivating 2.00±0.45 min only.
Conclusion: The PHF-3 showed satisfactory disintegration and in vitro dispersion time due to crospovidone and was
reported as the best formulation. The stability study and antioxidant property validate the PHF may represent a new
easily swallow dispersible tablet that may enhance drug permeability and advance bioavailability for oxidant needed
patients.