Hypoglycemic And Hypolipidemic Effect Of Celtis Philippensis Blanco On Albino Wistar Rats

Abstract

Diabetes is a chronic disease caused when the pancreas fails to produce sufficient insulin or when the body fails to
effectively use insulin in it. Insulin is a hormone that controls blood sugar. Approximately 463 million adults (20-79
years) were living with diabetes; by 2045 this will rise to 700 million. Celtis Philippines belongs to the Ulmaceae
family is a large fugacious tree distributed in most parts of India at an altitude of 1400 m. It is distributed in
indestructible forests. Qualitative phytochemical analysis of the aqueous, methanol, ethanol, ethyl acetate,
chloroform, and hexane plant extracts was carried out. Acute oral toxicity study of extracts of Celtis philippensis
leaves in mice have been determined. Glucose Tolerance Test and dexamethasone-induced evaluations were also
done to evaluate the anti-diabetic activity of the plant. The phytochemical screening results showed the presence
of phytochemical constituents, namely alkaloids, sterols, carbohydrates, glucosides, terpenoids and saponins,
tannins, gums and mucilage, and flavonoids. In the acute toxicity tests, administration of 2000 mg/kg doses of Celtis
philippensis leaf extract to albino mice did not show any visual symptoms of toxicity or mortality in animals during
the entire 14-days observation period. HDL level increased with extract and GLB group respectively when compared
to diabetic control.