Clinical Effectiveness Of Antifungl Drugs For Treatement Of Cryptococcus Isolates

Abstract

Cryptococcus spp., enhance pathogenicity to human beings, grow mechanism of adaptive survival within
environment host of immune reaction. Most of the fungal infections to humans caused the immune response of proinflammatory not in Cryptococcus spp. We analyzed the susceptibility for antifungal drugs in150 HIV patients with
meningitis. From them, 13 have Cryptococcal meningitis of which 10 were found to have primary episode and 3 have
relapse episode. The microbroth dilution method and epsilon meter test were performed to test antifungal
susceptibility; the isolates of C.neoformans and C.gattii were susceptible. We observed the MIC levels
ofamphotericin-B by micro dilution method observed from 0.10- 0.4μg/ml and 0.016-0.256μg/ml in E test. The MIC
for the drugs Fluconazole from 0.10 – 0.4 and 1.0-8.0 and Voriconazole also observed from 0.06-0.24 respectively.