Formulation, Characterization And Evaluation Of Topical Biodegradable Film Loaded With Levofloxacin Solid-Lipid Nano Carriers

Abstract

The major goal of this research was to develop a levofloxacin loaded solid lipid nanoparticles and formulate the topical biodegradable film of that nanoparticles and assess its prospects as a topical drug delivery system. The films were created utilising a solvent casting method using varied quantities of ethyl cellulose, hydroxypropyl methylcellulose K4M, hydroxypropyl methylcellulose, eudragit L-100, and Chitosan coalescence, as well as dibutyl phthalate as a plasticizer. The films were assessed for weight variation, thickness, percent moisture absorption, percentage moisture loss, folding endurance, percentage swelling index, percentage elongation, as well as an in vitro drug release study and an ex-vivo permeation investigation. The F5 formulation was discovered to be superior in terms of film. As a result, it was investigated as an optimum formulation. When compared to another formulation, the in-vitro drug release analysis shows that the F5 formulation had the highest drug release (91.34 percent) at the end of 8 hours.