Association Between Hormonal Contraception With Histopathology Grading Of Meningioma

Abstract

Introduction: Higher histopathological meningioma have poorer survival rate and higher recurrence rate than
benign histopathological meningioma. The relationship between the histopathological degree of meningioma and
the use of hormonal contraception has not been widely studied.
Aim: To identify the effect of using hormonal contraception on the histopathological degree of meningioma.
Methods: This research is a cross-sectional single centre study at RSUD dr. Soetomo, Surabaya, Indonesia for
meningioma patients who had surgery and histopathological examinations that were carried out between 2015-
2020. Two hundred and six participant’s data were analyzed statistically.
Results: There were 186 patients with a history of using hormonal contraception and 20 patients with no history of
using hormonal contraception. the average use of hormonal contraception in meningioma patients is above 4 years.
There was a significant difference in the duration of hormonal contraceptive use (p= 0.015) between meningioma
patients with benign and non-benign histopathological grades. There was no significant difference between the
history of using hormonal contraception (p= 0.084) and the type of hormonal contraception (p= 0.392) with the
histopathological degree of meningioma.
Conclusion: Duration of hormonal contraceptive use has a significant effect on the histopathological degree of
meningioma