Development And Characterization Of Floating Microspheres Of Losartan Potassium

Abstract

The objectives of this study to formulate the floating microspheres of Losartan Potassium in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability.
Materials method: Preparation of Floating Microspheres by Emulsification solvent diffusion techniques, Evaluation of various properties of floating microspheres.
Result and discussion: Emulsification solvent diffusion technology was built and tested using Glycerolmonstearate, Ethanol, and Chloromethane polymers. Losartan potassium microparticles. LP1 to LP9 were partitioned. FT-IR was used to investigate the drug-excipient interaction. The functional group region of the pure drug spectrum showed waves 615.29cm-1, 754.17cm-1, 1095.57cm-1, 1205.01cm-1, 1498.69cm-1, 1618.28cm-1,1676.14cm-1, 3415.93cm-1. The spectral peak for functional group stretching vibrations is 615.29 cm-1 (OH, CH, CH3, CH2OH). In the spectrum of Losartan microparticles, there are no interactions between the medicine and its excipients. Some formulations have limited yields due to microsphere loss after washing.
Conclusion: The polymer-to-drug ratio also affects particle size and drug release pattern. LP2 and LP9 have higher drug entrapment efficiency than LP1 to LP9. LP9 loaded 96% faster than F8. It produced large percentages, with LP9 yielding 96%. The flow properties of LP1–LP9 were measured. Carr's index and angle of repose measurements revealed no flow quality issues. 96.89 percent of the formulations showed progressive and sustained in vitro drug release over 8 hours. Losartan potassium microparticles were assessed for stability at 40°C, 2°C, and 75% RH. The drug's solubility and colour did not change in an in vitro drug release test.