Pre-Clinical Acute Toxicity And Hypoglycemic Study Of Phyllanthus Nirurion Mice Model

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Amit Kumar Sharma , Anju Pal , Krishan Pal


Phyllanthus niruri is herbal plants having potential medicinal remedial properties to cure many disease and
metabolic disorders. Here, we study the in vivo acute toxicity and hypoglycemic effect of whole phytochemical
extract of P niruri different varieties collected from Northern Uttar Pradesh and Uttarakhand region and their
phytochemicals ethanolic extract collected for the in vivo study in mice model. Plant extracts enriched with
different type biochemical, amino acids, saponins, tannins, flavonoids were administrated in mice model in
different concentration to check the acute toxicity. Subsequently, hypoglycemic effect of the plant extract was
studied in Streptozotocin (STZ) induced induce hyperglycemia or diabetic mice contrary to control and standard
drug group i.e., glibenclamide. Results showed that doses upto 1000 mg/kg body weight has lethal effect on
animals. However, the aqueous extract increases upto 400mg/kg body weight significantly reduces the blood
glucose level in hyperglycemic mice and shown that each sample has positive hypoglycemic efficiency.

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